Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Improved immune responses to influenza vaccination in the elderly using an immunostimulant patch
Ist Teil von
Vaccine, 2005-01, Vol.23 (7), p.946-950
Ort / Verlag
Oxford: Elsevier Ltd
Erscheinungsjahr
2005
Quelle
MEDLINE
Beschreibungen/Notizen
The elderly have greater morbidity and mortality due to influenza, and respond poorly to influenza vaccination compared to younger adults. This study was designed to determine if the adjuvant heat-labile enterotoxin from
Escherichia coli (LT), administered as an immunostimulant (IS) patch on the skin with influenza vaccination, improves influenza immune responses in the elderly. Three weeks following vaccination, hemagglutination inhibition (HAI) responses in LT IS patch recipients showed improvement over those of elderly receiving vaccine alone, as demonstrated by significance or trends in fold rise [A/Panama (
P = 0.004), A/New Caledonia (
P = 0.09)], seroconversion [A/New Caledonia (63% versus 40%,
P = 0.01), A/Panama (54% versus 36%,
P = 0.08)] and seroprotection [26%, 20% and 16% greater for the patch group for A/New Caledonia, A/Panama and B/Shandong strains, respectively]. The data suggest that an LT IS patch may further enhance influenza vaccine immune responses in the elderly.