Details

Autor(en) / Beteiligte

• Bachmann, Troels N., BSc
• Skov, Morten W., MD
• Rasmussen, Peter V., BSc
• Graff, Claus, MSc, PhD
• Pietersen, Adrian, MD
• Lind, Bent, MD, DMSci
• Struijk, Johannes J., MSc, PhD
• Olesen, Morten S., MSc, PhD
• Haunsø, Stig, MD, DMSci
• Køber, Lars, MD, DMSci
• Svendsen, Jesper H., MD, DMSci
• Holst, Anders G., MD, PhD
• Nielsen, Jonas B., MD, PhD

Titel

Electrocardiographic Tpeak–Tend interval and risk of cardiovascular morbidity and mortality: Results from the Copenhagen ECG study

Ist Teil von

• Heart rhythm, 2016-04, Vol.13 (4), p.915-924

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The electrocardiographic Tpeak–Tend interval is considered a novel risk marker of cardiac arrhythmias and cardiovascular death; however, results to date have been conflicting. Objective The purpose of this study was to investigate the association between this interval and the risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure, allowing for nonlinear relationships. Methods From primary care, 138,404 individuals were included and categorized into seven groups based on Tpeak–Tend interval. Cox regression models were used to describe the association between these groups and the risk of the selected outcomes. Results Compared with the reference groups (104–115 ms for all-cause mortality and 98–103 ms for all other outcomes), individuals with a Tpeak–Tend interval in lead V5 <5th percentile (58–77 ms) had hazard ratios of 1.29 (95% confidence interval [CI] 1.21–1.38, P <.001) for all-cause mortality, 1.31 (95% CI 1.15–1.50, P <.001) for cardiovascular death, 1.18 (95% CI 1.06–1.32, P = .003) for atrial fibrillation, and 1.52 (95% CI 1.33–1.74, P <.001) for heart failure. Individuals with a Tpeak–Tend interval ≥95th percentile (116–140 ms) had hazard ratios of 1.15 (95% CI 1.08–1.23, P <.001) for all-cause mortality, 1.30 (95% CI 1.15–1.47, P <.001) for cardiovascular death, 1.09 (95% CI 0.99–1.22, P = .088) for atrial fibrillation, and 1.28 (95% CI 1.12–1.46, P <.001) for heart failure. Similar results were obtained for leads II and V2. Conclusion We observed U-shaped associations between the Tpeak–Tend interval and risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure.