Details

Autor(en) / Beteiligte

• George, Stephen A., MD, PhD
• Bivens, Tiffany B., MS
• Howden, Erin J., PhD
• Saleem, Yasir, MD
• Galbreath, M. Melyn, PhD
• Hendrickson, Dianne, MS, APRN, FNP-C
• Fu, Qi, MD, PhD
• Levine, Benjamin D., MD

Titel

The international POTS registry: Evaluating the efficacy of an exercise training intervention in a community setting

Ist Teil von

• Heart rhythm, 2016-04, Vol.13 (4), p.943-950

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Background Postural orthostatic tachycardia syndrome (POTS) affects primarily young women and impairs quality of life. We found that in a research setting, exercise training along with lifestyle intervention is effective as a nondrug therapy for POTS. Objective To evaluate the efficacy of our exercise training/lifestyle intervention in POTS patients in a community environment. Methods We established a POTS registry and enrolled 251 patients (86% women, aged 26 ± 11 [SD] years) through their physicians. A 3-month program involving mild- to moderate-intensity endurance training (progressing from semirecumbent to upright, 3–5 times/wk, 30–45 min/session) plus strength training was implemented along with increasing salt/water intake. The program was delivered to the physicians, who oversaw training in their patients. A 10-minute stand test was performed at the physician’s office and patient quality of life was assessed using the 36-Item Short Form Health Survey. Results One hundred and three patients completed the program. Of those that completed, 71% no longer qualified for POTS and were thus in remission. The increase in heart rate from supine to 10-minute stand was markedly lower (23 ± 14 vs 46 ± 17 beats/min before intervention; P < .001), while patient quality of life was improved dramatically after intervention ( P < .001). Of those who were followed for 6–12 months (n = 31), the effect was persistent. Conclusions A training/lifestyle intervention program can be implemented in a community setting with physician supervision and is effective in the treatment of POTS. It remains to be determined whether exercise can be an effective long-term treatment strategy for this condition, though patients are encouraged to maintain an active lifestyle indefinitely.