Details

Autor(en) / Beteiligte

• Liu, Zhenyin
• Xu, Yong
• An, Jie
• Wang, Junjing
• Yin, Xiangyuan
• Huang, Ruiwang
• Lv, Xiaofei
• Chen, Lina
• Wang, Wensheng
• Qiu, Shijun

Titel

Altered Brain White Matter Integrity in Temporal Lobe Epilepsy: A TBSS Study

Ist Teil von

• Journal of neuroimaging, 2015-05, Vol.25 (3), p.460-464

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• ABSTRACT BACKGROUND AND PURPOSE The aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract‐based spatial statistics (TBSS). METHODS Twenty TLE patients and 22 age‐ and gender‐matched normal controls were included in this study. Voxel‐wise analyses of multiple diffusion metrics, including fractional anisotropy (FA) and mean diffusivity (MD) were performed with TBSS. RESULTS TLE patients exhibited significantly reduced FA in widespread white matter regions including bilateral limbic circuit, corpus callosum, thalamus, internal/external capsule, temporooccipital connections, frontotemporal connections; increase of MD was exhibited significantly almost in the left hemisphere. A significant decrease in global FA integrity was shown in epilepsy subjects compared to healthy controls. Furthermore, it exhibited a significant positive correlation between the disease duration and MD of whole brain. CONCLUSIONS TLE is associated with widespread abnormalities in cerebral white matter tracts and these changes may have important clinical consequences.