Behavioural brain research, 2004-10, Vol.154 (2), p.339-343
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats
- Ist Teil von
- Behavioural brain research, 2004-10, Vol.154 (2), p.339-343
- Ort / Verlag
- Shannon: Elsevier B.V
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We studied the involvement of hippocampal protein synthesis-, PKA-, and MAP kinase-dependent processes in short- (STM) and long-term memory (LTM) for inhibitory avoidance task. Fifteen minutes before or immediately after training rats received intrahippocampal infusions of vehicle, the protein synthesis inhibitor anisomycin, the PKA inhibitor Rp-cAMPs or the MAPKK inhibitor PD098059. The results show that STM recruits PKA and MAPK, whereas, LTM depends on PKA activity and protein synthesis during the early post-training period.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-4328eISSN: 1872-7549DOI: 10.1016/j.bbr.2004.03.001Titel-ID: cdi_proquest_miscellaneous_17736034
- Format
- –
- Schlagworte
- Animal, Animals, Avoidance Learning - drug effects, Behavior, Animal, Biological and medical sciences, cAMP-dependent protein kinase (PKA), Cyclic AMP-Dependent Protein Kinases - physiology, Enzyme Inhibitors - pharmacology, Fundamental and applied biological sciences. Psychology, Hippocampus, Hippocampus - drug effects, Hippocampus - metabolism, Learning. Memory, Long-term memory, Male, Memory, Memory - classification, Memory - drug effects, Memory - physiology, Mitogen-activated protein kinase (MAPK), Mitogen-Activated Protein Kinases - physiology, Protein synthesis, Proteins - metabolism, Psychology. Psychoanalysis. Psychiatry, Psychology. Psychophysiology, Rats, Rats, Wistar, Reaction Time - drug effects, Short-term memory, Statistics, Nonparametric, Time Factors