Details

Autor(en) / Beteiligte

• Bodem, Jens Philipp, MD, DDS
• Schaal, Carolin, DDS
• Kargus, Steffen, MD, DDS
• Saure, Daniel, PhD
• Mertens, Christian, DDS
• Engel, Michael, MD, DDS
• Hoffmann, Jürgen, MD, DDS
• Freudlsperger, Christian, MD, DDS

Titel

Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III

Ist Teil von

• Oral surgery, oral medicine, oral pathology and oral radiology, 2016-04, Vol.121 (4), p.367-372

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective The value of surgery in advanced stages of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is still controversial. Hence, we evaluated the effect of surgical therapy in BRONJ stages II and III in combination with a standardized perioperative adjuvant treatment. Study Design We included 39 patients who presented with BRONJ in a total of 47 locations and stages II (n = 23) and III (n = 24). All patients had exclusively received a monthly intravenous application of zoledronic acid. Surgical therapy consisted of complete removal of the necrotic jaw, accompanied by a standardized perioperative adjuvant treatment including intravenous antibiotic prophylaxis, gastric feeding, and an antimicrobiologic mouth rinsing. Results Overall, 35 (74.5%) of the 47 BRONJ sites were treated successfully, with success defined as complete mucosal healing of the exposed jaw (n = 24) or as relative healing when surgical therapy downscaled BRONJ II or III to asymptomatic BRONJ stage I (n = 11). Interestingly, perioperative adjuvant treatment or bisphosphonate therapy parameters showed no statistical effect on the treatment outcome. Conclusions The results of the present study prove the effectiveness of surgical therapy for BRONJ stage II or III.