Details

Autor(en) / Beteiligte

• Kodama, Yasumitsu
• Yoshikai, Yoshihiro
• Tamura, Yasushi
• Wakana, Shigeharu
• Takagi, Ritsuo
• Niwa, Ohtsura
• Kominami, Ryo

Titel

The D5Mit7 locus on mouse chromosome 5 provides resistance to γ-ray-induced but not N-methyl-N-nitrosourea-induced thymic lymphomas

Ist Teil von

• Carcinogenesis (New York), 2004-01, Vol.25 (1), p.143-148

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2004

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Susceptibility to γ-ray induction of thymic lymphomas in mouse strains is controlled by low-penetrance genetic variant alleles. Our previous genome-wide scan of a mouse backcross between BALB/c and MSM strains suggested the existence of a BALB/c resistance locus near D5Mit5 on chromosome 5. To confirm this resistance, we produced congenic mice carrying a 28.4 cM region between D5Mit4 and D5Mit315 from the MSM parental strain on the BALB/c background. Lymphomas were induced in their progeny by γ-ray irradiation or administration of N-methyl-N-nitrosourea (MNU), an alkylating agent. The incidence of radiogenic lymphomas was 87.5% in mice of the M/M genotype at D5Mit7, significantly higher than the 46% incidence in mice of the C/M genotype, indicating highly significant linkage between the locus and the resistance (P = 0.000054). In contrast, the frequencies of MNU-induced thymic lymphomas were similar between the two genotypes (P = 0.35 in χ2 test). These results confirm the presence of a resistance allele for γ-ray induction of thymic lymphomas near the D5Mit7 locus and strongly suggest that this locus modifies carcinogenic risk from exposure to radiation but not to alkylating agents.