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Mechanism of hsp70i Gene Bookmarking
Science (American Association for the Advancement of Science), 2005-01, Vol.307 (5708), p.421-423
2005

Details

Autor(en) / Beteiligte
Titel
Mechanism of hsp70i Gene Bookmarking
Ist Teil von
  • Science (American Association for the Advancement of Science), 2005-01, Vol.307 (5708), p.421-423
Ort / Verlag
Washington, DC: American Association for the Advancement of Science
Erscheinungsjahr
2005
Link zum Volltext
Quelle
American Association for the Advancement of Science
Beschreibungen/Notizen
  • In contrast to most genomic DNA in mitotic cells, the promoter regions of some genes, such as the stress-inducible hsp70i gene that codes for a heat shock protein, remain uncompacted, a phenomenon called bookmarking. Here we show that hsp70i bookmarking is mediated by a transcription factor called HSF2, which binds this promoter in mitotic cells, recruits protein phosphatase 2A, and interacts with the CAP-G subunit of the condensin enzyme to promote efficient dephosphorylation and inactivation of condensin complexes in the vicinity, thereby preventing compaction at this site. Blocking HSF2-mediated bookmarking by HSF2 RNA interference decreases hsp70i induction and survival of stressed cells in the G₁ phase, which demonstrates the biological importance of gene bookmarking.
Sprache
Englisch
Identifikatoren
ISSN: 0036-8075
eISSN: 1095-9203
DOI: 10.1126/science.1106478
Titel-ID: cdi_proquest_miscellaneous_17693700
Format
–
Schlagworte
Adenosine Triphosphatases - metabolism, Analysis, Antibodies, Biological and medical sciences, Cell cycle, cell proliferation, Cell division, Cell Line, Tumor, Cell physiology, Cellular immunity, Chromatin, Chromatin Immunoprecipitation, Chromosomes, Cytokinesis, Deoxyribonucleic acid, DNA, DNA-Binding Proteins - metabolism, Enzymes, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Genes, Genetics, Genomes, Genotype & phenotype, Heat-Shock Proteins - genetics, Heat-Shock Proteins - metabolism, HeLa Cells, Hot Temperature, HSP70 Heat-Shock Proteins - genetics, Humans, Immunoprecipitation, Interphase, K562 cells, Mitosis, Molecular and cellular biology, Multiprotein Complexes, Observations, Phosphatases, Phosphoprotein Phosphatases - metabolism, Phosphorylation, Promoter Regions, Genetic, Protein Binding, Protein Phosphatase 2, Protein Subunits - metabolism, RNA Interference, RNA, Small Interfering - pharmacology, Small interfering RNA, T lymphocytes, Transcription Factors - genetics, Transcription Factors - metabolism, Two-Hybrid System Techniques

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