Details

Autor(en) / Beteiligte

• Nencha, Umberto
• Rahimian, Amithys
• Giry, Marine
• Sechi, Andrea
• Mokhtari, Karima
• Polivka, Marc
• Schmitt, Yohann
• Di Stefano, Anna-Luisa
• Alentorn, Agusti
• Labussière, Marianne
• Sanson, Marc

Titel

TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas

Ist Teil von

• Journal of neuro-oncology, 2016-02, Vol.126 (3), p.441-446

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• TERT promoter ( TERT p) mutation is the most common mutation in glioblastomas. It creates a putative binding site for Ets/TCF transcription factors, enhancing telomerase expression and activity, whereas the rs2853669 variant disrupts another Ets/TCF binding. We explore here the interaction between these two alterations, tumor genomic profile and the impact on prognosis. The TERT p and rs2853669 statuses were determined and confronted with the outcome and molecular profile, i.e., loss of chromosome 10q, CDKN2A deletion, IDH mutation, EGFR amplification, MGMT promoter methylation. 651 glioblastomas were selected (sex ratio = 1.35, median age 60.4 years, median survival 13.5 months). The TERT p mutation found in 481 patients (74 %) was independent from rs2853669 genotypes. TERT p mutation, but not rs2853669 status, was associated with older age (61.4 vs. 52.8 years). rs2853669 status had no impact on overall survival (OS) either in mutated TERT p or wild-type TERT p. Neither rs2736100 ( TERT , 5q15.33) nor rs192011116 ( TERC , 3q26.2) status had any impact on survival or showed any association with a TERT p mutation. The TERT p mutation was associated with EGFR amplification chromosome 10q loss, CDKN2A deletion and IDH wt. EGFR amplification was associated with a better outcome in TERTp mutated GBM, and a worse outcome in TERTp WT. This study—the largest analyzing the TERT p mutation and the rs2853669 polymorphism—fails to find any prognostic impact of rs2853669. It confirms the dual prognostic impact of EGFR amplification depending on TERT p status.