Details

Autor(en) / Beteiligte

• Schmiedchen, Bettina
• Longardt, Ann Carolin
• Loui, Andrea
• Bührer, Christoph
• Raila, Jens
• Schweigert, Florian J.

Titel

Effect of vitamin A supplementation on the urinary retinol excretion in very low birth weight infants

Ist Teil von

• European journal of pediatrics, 2016-03, Vol.175 (3), p.365-372

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2016

Quelle

SpringerLink

Beschreibungen/Notizen

• Despite high-dose vitamin A supplementation of very low birth weight infants (VLBW, <1500 g), their vitamin A status does not improve substantially. Unknown is the impact of urinary retinol excretion on the serum retinol concentration in these infants. Therefore, the effect of high-dose vitamin A supplementation on the urinary vitamin A excretion in VLBW infants was investigated. Sixty-three VLBW infants were treated with vitamin A (5000 IU intramuscular, 3 times/week for 4 weeks); 38 untreated infants were classified as control group. On days 3 and 28 of life, retinol, retinol-binding protein 4 (RBP4), glomerular filtration rate, proteinuria, and Tamm–Horsfall protein were quantified in urine. On day 3 of life, substantial retinol and RBP4 losses were found in both groups, which significantly decreased until day 28. Notwithstanding, the retinol excretion was higher ( P  < 0.01) under vitamin A supplementation as compared to infants of the control group. On day 28 of life, the urinary retinol concentrations were predictive for serum retinol concentrations in the vitamin A treated ( P  < 0.01), but not in the control group ( P  = 0.570). Conclusion : High urinary retinol excretion may limit the vitamin A supplementation efficacy in VLBW infants. Advanced age and thus postnatal kidney maturation seems to be an important contributor in the prevention of urinary retinol losses. What is Known: • VLBW infants have low vitamin A status , even after 4 - week high - dose vitamin A supplementation [Longardt AC, Eur J Clin Nutr 2014 ; Schmiedchen B, Longardt AC, Buehrer C, Raila J, Loui A, Schweigert FJ Neonatology 105:155-160, 2014 ] • VLBW infants excrete high amounts of retinol [Nagl B, Loui A, Raila J, Felderhoff-Mueser U, Obladen M, Schweigert FJ Pediatr Nephrol 24:61-66, 2009 ] What is New: • Urine retinol excretion reduces with increasing age of VLBW infants and is not suitable to assess vitamin A status in VLBW infants • High urinary retinol excretion may limit vitamin A supplementation efficacy in VLBW infants