Details

Autor(en) / Beteiligte

• Ewaisha, Radwa
• Gawryletz, Chelsea D.
• Anderson, Karen S.

Titel

Crucial considerations for pipelines to validate circulating biomarkers for breast cancer

Ist Teil von

• Expert review of proteomics, 2016-02, Vol.13 (2), p.201-211

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Despite decades of progress in breast imaging, breast cancer remains the second most common cause of cancer mortality in women. The rapidly proliferative breast cancers that are associated with high relapse rates and mortality frequently present in younger women, in unscreened individuals, or in the intervals between screening mammography. Biomarkers exist for monitoring metastatic disease, such as CEA, CA27.29 and CA15-3, but there are no circulating biomarkers clinically available for early detection, prognosis, or monitoring for clinical relapse. There has been significant progress in the discovery of potential circulating biomarkers, including proteins, autoantibodies, nucleic acids, exosomes, and circulating tumor cells, but the vast majority of these biomarkers have not progressed beyond initial research discovery, and none have yet been approved for clinical use in early stage disease. Here, the authors review the crucial considerations of developing pipelines for the rapid evaluation of circulating biomarkers for breast cancer.