Details

Autor(en) / Beteiligte

• Weng, Qunhong
• Wang, Binju
• Wang, Xuebin
• Hanagata, Nobutaka
• Li, Xia
• Liu, Dequan
• Wang, Xi
• Jiang, Xiangfen
• Bando, Yoshio
• Golberg, Dmitri

Titel

Highly Water-Soluble, Porous, and Biocompatible Boron Nitrides for Anticancer Drug Delivery

Ist Teil von

• ACS nano, 2014-06, Vol.8 (6), p.6123-6130

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Developing materials for “Nano-vehicles” with clinically approved drugs encapsulated is envisaged to enhance drug therapeutic effects and reduce the adverse effects. However, design and preparation of the biomaterials that are porous, nontoxic, soluble, and stable in physiological solutions and could be easily functionalized for effective drug deliveries are still challenging. Here, we report an original and simple thermal substitution method to fabricate perfectly water-soluble and porous boron nitride (BN) materials featuring unprecedentedly high hydroxylation degrees. These hydroxylated BNs are biocompatible and can effectively load anticancer drugs (e.g., doxorubicin, DOX) up to contents three times exceeding their own weight. The same or even fewer drugs that are loaded on such BN carriers exhibit much higher potency for reducing the viability of LNCaP cancer cells than free drugs.