Cancer letters, 2016-02, Vol.371 (2), p.301-313
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Molecular mechanisms of microRNAs in regulating epithelial–mesenchymal transitions in human cancers
- Ist Teil von
- Cancer letters, 2016-02, Vol.371 (2), p.301-313
- Ort / Verlag
- Ireland: Elsevier B.V
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • We summarize the feedback loop mechanisms regulating EMT between miRNAs and EMT-related molecules. • We summarize different miRNAs function as oncogenes or tumor suppressor to inhibit or promote EMT. • We summarize one miRNA has dual effects on EMT in the different human cancers. • We summarize miRNAs can inhibit or promote EMT through regulating methylation or hydroxymethylation. • We summarize the mechanism of miRNAs controlling EMT to alter tumor chemoradiosensitivity or chemoradioresistance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2015.11.043Titel-ID: cdi_proquest_miscellaneous_1762027296
- Format
- –
- Schlagworte
- Animals, Binding sites, Biomarkers, Tumor - genetics, Biomarkers, Tumor - metabolism, Breast cancer, Cancer, Cervical cancer, EMT, Epithelial-Mesenchymal Transition, Feedback, Gastric cancer, Gene expression, Gene Expression Regulation, Neoplastic, Genotype & phenotype, Hematology, Oncology and Palliative Medicine, Humans, Liver cancer, Lung cancer, Metastasis, MicroRNAs, MicroRNAs - genetics, MicroRNAs - metabolism, miRNAs, Neoplasms - genetics, Neoplasms - metabolism, Neoplasms - pathology, Neoplasms - therapy, Ovarian cancer, Prognosis, Signal Transduction, Tumorigenesis, Tumors