Details

Autor(en) / Beteiligte

• Santilli, Francesca
• Guagnano, Maria Teresa
• Innocenti, Paolo
• Aceto, Liberato
• Vazzana, Natale
• Lattanzio, Stefano
• Liani, Rossella
• Tripaldi, Romina
• Creato, Valeria
• Romano, Mario
• Davì, Giovanni

Titel

Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding

Ist Teil von

• Circulation Journal, 2016/01/25, Vol.80(2), pp.502-511

Ort / Verlag

Japan: The Japanese Circulation Society

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background:Circulating pentraxin 3 (PTX3), the main regulator of the inflammatory response, rapidly increases following cardiovascular events, and low PTX3 is associated with high body mass index.Methods and Results:We conducted a 12-month longitudinal study, to test the hypothesis that laparoscopic adjustable gastric banding (LAGB)-induced weight loss was associated with changes in platelet activation markers and PTX3. Twelve obese patients, scheduled to undergo LAGB, were enrolled at the University Obesity Center. Urinary 11-dehydro-thromboxane (Tx)B2excretion rate was measured on radioimmunoassay, and PTX3 and CD40L were determined on immunoassay. Plasma PTX3 increased by 178.8 and 214.9% (P<0.0001), respectively, 6 and 12 months after LAGB. High-sensitivity CRP decreased by 24 and 29.7% (P<0.0001), whereas CD40L decreased by 64.3 and 58.6% (P=0.002), respectively. Urinary 11-dehydro-TxB2decreased from 1,443 to 715 and 564 pg/mg creatinine, respectively 6 months and 12 months after LAGB (P<0.0001). PTX3 was inversely related to platelet activation markers, 11-dehydro-TxB2and CD40L. Moreover, multiple regression analysis on pooled data showed that plasma PTX3 was an independent predictor of urinary 11-dehydro-TxB2.Conclusions:There is an association between inflammation, platelet activation and metabolic dysfunction in obesity, and PTX3 is a key player within these circuits. (Circ J 2016; 80: 502–511)