Details

Autor(en) / Beteiligte

• He, Xiao-Peng
• Tian, He

Titel

Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2016-01, Vol.12 (2), p.144-160

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Ever since the discovery of graphene, increasing efforts have been devoted to the use of this stellar material as well as the development of other graphene‐like materials such as thin‐layer transition metal dichalcogenides and oxides (TMD/Os) for a variety of applications. Because of their large surface area and unique optical properties, these two‐dimensional materials with a size ranging from the micro‐ to the nanoscale have been employed as the substrate to construct photoluminescence architectures for disease diagnosis as well as theranostics. These architectures are built through the simple self‐assembly of labeled biomolecular probes with the substrate material, leading to signal quenching. Upon the specific interaction of the architecture with a target biomarker, the signal can be spontaneously restored in a reversible manner. Meanwhile, by co‐loading therapeutic agents and employing the inherent photo‐thermal properties of the material substrates, a combined disease imaging and therapy (theranostics) can be achieved. This review highlights the latest advances in the construction and application of graphene and TMD/O based thin‐layer material composites for single‐target and multiplexed detection of a variety of biomarkers and theranostics. These versatile material architectures, owing to their ease in preparation, low cost and flexibility in functionalization, provide promising tools for both basic biochemical research and clinical applications. Developments in photoluminescence architectures, constructed by simple supramolecular self‐assembly between graphene and graphene‐like thin‐layer materials and labeled biomolecular probes, are summarized. These material composites show a diverse range of diagnostic as well as theranostic applications, providing a new generation of promising tools for the clinical use.