Details

Autor(en) / Beteiligte

• Lin, C.-H.
• Wei, C.-C.
• Lin, C.-L.
• Lin, W.-C.
• Kao, C.-H.

Titel

Childhood type 1 diabetes may increase the risk of atopic dermatitis

Ist Teil von

• British journal of dermatology (1951), 2016-01, Vol.174 (1), p.88-94

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Wiley HSS Collection

Beschreibungen/Notizen

• Summary Background Epidemiological investigations have examined the association between type 1 diabetes mellitus (T1DM) and atopic disease, but have obtained conflicting results. Objectives To analyse the association between T1DM and atopic dermatitis (AD) in a population‐based, retrospective cohort study that investigated the hypothesis that childhood T1DM is a risk factor for subsequent AD. Methods From claims data of the National Health Insurance programme of Taiwan, we identified 3386 patients with T1DM newly diagnosed from 1998 to 2011 and 12 725 randomly selected controls without T1DM. These were frequency matched by age, sex and year of diagnosis. Both cohorts were followed up until the end of 2011 to evaluate the AD risk. We used Cox proportional hazards regression models to analyse the risk of AD. Results The overall incidence rate of AD was 1·40‐fold (significantly) higher in the T1DM cohort than in the non‐T1DM cohort (3·31 vs. 2·35 per 1000 person years). After adjustment for potential risk factors, the overall risk of AD remained higher in the T1DM cohort [adjusted hazard ratio (HR) 1·76, 95% confidence interval (CI) 1·29–2·39] than in those without T1DM. Compared with the non‐T1DM cohort, the patients with T1DM with more emergency room visits (adjusted HR 30·1, 95% CI 18·7–48·5) or hospitalizations (adjusted HR 70·3, 95% CI 45·6–114·5) had a higher risk of subsequent AD. Conclusions This nationwide, retrospective cohort study demonstrates that childhood T1DM may increase the risk of AD. What's already known about this topic? Some studies have reported that atopic dermatitis (AD) is associated with a lower risk of type 1 diabetes mellitus (T1DM). An inverse association was theorized between T1DM and AD because the T‐helper 1/2 immune responses of these two diseases are mutually inhibitory. What does this study add? This nationwide, retrospective cohort study demonstrates that childhood T1DM may increase the risk of AD. The overall AD incidence rate was 1·40‐fold (significantly) higher in the T1DM cohort than in the non‐T1DM cohort (3·31 vs. 2·35 per 1000 person years). Linked Comment: Ezzedine and Barbarot, Br J Dermatol 2016; 174: 16. Plain language summary available online