Details

Autor(en) / Beteiligte

• Garman, Katherine S
• Kruger, Leandi
• Thomas, Samantha
• Swiderska-Syn, Marzena
• Moser, Barry K
• Diehl, Anna Mae
• McCall, Shannon J

Titel

Ductal metaplasia in oesophageal submucosal glands is associated with inflammation and oesophageal adenocarcinoma

Ist Teil von

• Histopathology, 2015-12, Vol.67 (6), p.771-782

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Aims Recent studies have suggested that oesophageal submucosal gland (ESMG) ducts harbour progenitor cells that may contribute to oesophageal metaplasia. Our objective was to determine whether histological differences exist between the ESMGs of individuals with and without oesophageal adenocarcinoma (EAC). Methods and results We performed histological assessment of 343 unique ESMGs from 30 control patients, 24 patients with treatment‐naïve high‐grade columnar dysplasia (HGD) or EAC, and 23 non‐EAC oesophagectomy cases. A gastrointestinal pathologist assessed haematoxylin and eosin‐stained ESMG images by using a scoring system that assigns individual ESMG acini to five histological types (mucous, serous, oncocytic, dilated, or ductal metaplastic). In our model, ductal metaplastic acini were more common in patients with HGD/EAC (12.7%) than in controls (3.5%) (P = 0.006). We also identified greater proportions of acini with dilation (21.9%, P < 0.001) and, to a lesser extent, ductal metaplasia (4.3%, P = 0.001) in non‐EAC oesophagectomy cases than in controls. Ductal metaplasia tended to occur in areas of mucosal ulceration or tumour. Conclusions We found a clear association between ductal metaplastic ESMG acini and HGD/EAC. Non‐EAC cases had dilated acini and some ductal dilation. Because ESMGs and ducts harbour putative progenitor cells, these associations could have significance for understanding the pathogenesis of EAC.