Lung cancer (Amsterdam, Netherlands), 2015-12, Vol.90 (3), p.509-515
2015
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- Autor(en) / Beteiligte
- Titel
- EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291
- Ist Teil von
- Lung cancer (Amsterdam, Netherlands), 2015-12, Vol.90 (3), p.509-515
- Ort / Verlag
- Ireland: Elsevier B.V
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Multiple platforms were compared for detection of EGFR mutations in plasma ctDNA. • Digital and traditional PCR assays were assessed using plasma from AZD9291 trials. • Multiple platforms enabled robust detection of common EGFR-sensitizing mutations. • cobas® and BEAMing assays showed >70% sensitivity for plasma T790M detection. • Genomic heterogeneity of T790M may explain most plasma-tissue discordance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0169-5002eISSN: 1872-8332DOI: 10.1016/j.lungcan.2015.10.004Titel-ID: cdi_proquest_miscellaneous_1760889847
- Format
- –
- Schlagworte
- Acrylamides - pharmacology, Acrylamides - therapeutic use, Aniline Compounds - pharmacology, Aniline Compounds - therapeutic use, Antineoplastic Agents - pharmacology, Antineoplastic Agents - therapeutic use, AZD9291, Biomarkers, Tumor, Carcinoma, Non-Small-Cell Lung - blood, Carcinoma, Non-Small-Cell Lung - diagnosis, Carcinoma, Non-Small-Cell Lung - drug therapy, Carcinoma, Non-Small-Cell Lung - genetics, Circulating tumor DNA, DNA Mutational Analysis - methods, DNA Mutational Analysis - standards, DNA, Neoplasm - blood, Epidermal growth factor receptor mutation, ErbB Receptors - antagonists & inhibitors, ErbB Receptors - genetics, Female, Hematology, Oncology and Palliative Medicine, Humans, Lung Neoplasms - blood, Lung Neoplasms - diagnosis, Lung Neoplasms - drug therapy, Lung Neoplasms - genetics, Male, Mutation, Non-small cell lung cancer, Polymerase Chain Reaction - methods, Polymerase Chain Reaction - standards, Protein Kinase Inhibitors - pharmacology, Protein Kinase Inhibitors - therapeutic use, Pulmonary/Respiratory, Reproducibility of Results, Sensitivity and Specificity, T790M