Details

Autor(en) / Beteiligte

• Kanda, Mitsuro
• Nomoto, Shuji
• Oya, Hisaharu
• Takami, Hideki
• Shimizu, Dai
• Hibino, Soki
• Hashimoto, Ryoji
• Kobayashi, Daisuke
• Tanaka, Chie
• Yamada, Suguru
• Fujii, Tsutomu
• Nakayama, Goro
• Sugimoto, Hiroyuki
• Koike, Masahiko
• Fujiwara, Michitaka
• Kodera, Yasuhiro

Titel

The Expression of Melanoma-Associated Antigen D2 Both in Surgically Resected and Serum Samples Serves as Clinically Relevant Biomarker of Gastric Cancer Progression

Ist Teil von

• Annals of surgical oncology, 2016-02, Vol.23 (Suppl 2), p.214-221

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2016

Link zum Volltext

Quelle

SpringerLink

Beschreibungen/Notizen

• Background Sensitive biomarkers are necessary for risk classification of patients with gastric cancer (GC), especially ones at risk of distant metastases. Melanoma-associated antigen (MAGE)-D2 has been reported to play a role in the process of cell adhesion and metastatic potential of tumor cells in colorectal cancer. The purpose of this study was to identify a novel clinically relevant biomarker of GC. Methods Expression analysis of MAGE-D2 was conducted in GC cell lines and clinical samples (surgical specimen and serum) in both mRNA and protein level. Correlations between MAGE-D2 expression status and clinicopathological factors were evaluated. Results MAGE-D2 mRNA expression levels were similar between GC tissues and the corresponding normal adjacent tissues and were independent of GC differentiation or subtype. In 101 (45 %) of 225 patients, the expression level of MAGE - D2 mRNA was increased in GC tissues compared with the corresponding normal adjacent tissues. Increased expression of MAGE - D2 mRNA in GC tissues was associated with distant metastasis and early recurrence and was an independent prognostic factor (hazard ratio 2.27, 95 % confidence interval 1.39–3.74, P  = 0.001). There was a stepwise increase in serum MAGE - D2 level going from healthy volunteers to patients with localized GC and then to those with extended GC (stage IV). Patients with preoperative serum MAGE - D2 levels >130 pg/ml had a more unfavorable prognosis than those with levels ≤130 pg/ml. Conclusion MAGE - D2 was associated with metastatic potential of GC and may represent a promising biomarker, both in gastric tissues and serum samples, for malignant behavior of GC.