Details

Autor(en) / Beteiligte

• Chou, H.‐Y.
• Chen, C.‐B.
• Cheng, C.‐Y.
• Chen, Y.‐A.
• Ng, C. Y.
• Kuo, K.‐L.
• Chen, W.‐L.
• Chen, C.‐H.

Titel

Febuxostat‐associated drug reaction with eosinophilia and systemic symptoms (DRESS)

Ist Teil von

• Journal of clinical pharmacy and therapeutics, 2015-12, Vol.40 (6), p.689-692

Ort / Verlag

England: Hindawi Limited

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary What is known and objective Febuxostat is recommended as an alternative drug for gouty patients with a history of allopurinol hypersensitivity or carrying the HLA‐B*5801 allele. Case summary An 81‐year‐old man with the medical history of gout presented to our clinic with generalized rashes for 2 days. After taking febuxostat for 2 days, he developed generalized skin rash with high fever. Laboratory tests showed elevated liver enzymes and acute kidney injury. What is Known and Objective This is the first identified case of febuxostat‐associated DRESS. Febuxostat should be withdrawn immediately when DRESS is observed to avoid further serious complications. Time course of liver function tests.