Details

Autor(en) / Beteiligte

• Hagendorens, M. M.
• Bridts, C. H.
• Lauwers, K.
• Van Nuijs, S.
• Ebo, D. G.
• Vellinga, A.
• De Clerck, L. S.
• Van Bever, H. P.
• Weyler, J. J.
• Stevens, W. J.

Titel

Perinatal risk factors for sensitization, atopic dermatitis and wheezing during the first year of life (PIPO study)

Ist Teil von

• Clinical and experimental allergy, 2005-06, Vol.35 (6), p.733-740

Ort / Verlag

Oxford, UK: Blackwell Publishing

Erscheinungsjahr

2005

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Summary Objective To evaluate the influence of perinatal environmental factors on early sensitization, atopic dermatitis and wheezing during the first year. Methods Information on pregnancy‐related factors, parental atopic history, environmental factors and the clinical course of the infant until age one was gathered by questionnaires, as part of a prospective birth cohort study (Prospective study on the Influence of Perinatal factors on the Occurrence of asthma and allergies [PIPO‐study]). Quantification of total and specific IgE was performed in 810 children and their parents. Results Early sensitization was found in 107/810 (13%) of the infants. Multiple regression analysis showed that specific IgE in fathers was a risk factor for early sensitization in their daughters (adjusted odds ratios (ORadj) 2.21 (95% confidence interval (CI) 1.10–4.49); P=0.03), whereas in boys, day care attendance was shown to be protective for early sensitization (ORadj 0.38 (95% CI 0.20–0.71); P=0.001). Atopic dermatitis occurred in 195/792 infants (25%). Specific IgE in the mother (ORadj 1.52 (95% CI 1.06–2.19); P=0.02) and in the infant (ORadj 4.20 (95% CI 2.63–6.68); P<0.001) were both risk factors for the occurence of atopic dermatitis, whereas postnatal exposure to cats was negatively associated with atopic dermatitis (ORadj 0.68 (0.47–0.97); P=0.03). Postnatal exposure to cigarette smoke (ORadj 3.31 (95% CI 1.79–6.09); P<0.001) and day care attendance (ORadj 1.96 (95% CI 1.18–3.23); P=0.009) were significantly associated with early wheezing, which occurred in 25% (197/795) of the infants. Conclusion The effect of paternal sensitization and day care attendance on sensitization is gender dependent. Maternal sensitization predisposes for atopic dermatitis, whereas postnatal exposure to cats had a protective effect.