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BibTeX
Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: An mFISH study
Genes chromosomes & cancer, 2005-09, Vol.44 (1), p.1-9
Hande, M. Prakash
Azizova, Tamara V.
Burak, Ludmilla E.
Khokhryakov, Valentin F.
Geard, Charles R.
Brenner, David J.
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Hande, M. Prakash
Azizova, Tamara V.
Burak, Ludmilla E.
Khokhryakov, Valentin F.
Geard, Charles R.
Brenner, David J.
Titel
Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: An mFISH study
Ist Teil von
Genes chromosomes & cancer, 2005-09, Vol.44 (1), p.1-9
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Quelle
MEDLINE
Beschreibungen/Notizen
Long‐lived, sensitive, and specific biomarkers of particular mutagenic agents are much sought after and potentially have broad applications in the fields of cancer biology, epidemiology, and prevention. Many clastogens induce a spectrum of chromosome aberrations, and some of them can be exploited as biomarkers of exposure. Densely ionizing radiation, for example, alpha particle radiation (from radon or plutonium) and neutron radiation, preferentially induces complex chromosome aberrations, which can be detected by the 24‐color multifluor fluorescence in situ hybridization (mFISH) technique. We report the detection and quantification of stable complex chromosome aberrations in lymphocytes of healthy former nuclear‐weapons workers, who were exposed many years ago to plutonium, gamma rays, or both, at the Mayak weapons complex in Russia. We analyzed peripheral‐blood lymphocytes from these individuals for the presence of persistent complex chromosome aberrations. A significantly elevated frequency of complex chromosome translocations was detected in the highly exposed plutonium workers but not in the group exposed only to high doses of gamma radiation. No such differences were found for simple chromosomal aberrations. The results suggest that stable complex chromosomal translocations represent a long‐lived, quantitative, low‐background biomarker of densely ionizing radiation for human populations exposed many years ago. © 2005 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1045-2257
eISSN: 1098-2264
DOI: 10.1002/gcc.20217
Titel-ID: cdi_proquest_miscellaneous_17539029
Format
–
Schlagworte
Chromosome Aberrations - radiation effects
,
Chromosomes, Human - radiation effects
,
Humans
,
In Situ Hybridization, Fluorescence
,
Nuclear Reactors
,
Occupational Exposure
,
Plutonium
,
Radiation, Ionizing
,
Radon
,
Russia
,
Translocation, Genetic
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