Details

Autor(en) / Beteiligte

• Feagan, Brian G
• Fedorak, Richard N
• Irvine, E. Jan
• Wild, Gary
• Sutherland, Lloyd
• Steinhart, A. Hillary
• Greenberg, Gordon R
• Koval, John
• Wong, Cindy J
• Hopkins, Marybeth
• Hanauer, Stephen B
• McDonald, John W.D

Titel

A Comparison of Methotrexate with Placebo for the Maintenance of Remission in Crohn's Disease

Ist Teil von

• The New England journal of medicine, 2000-06, Vol.342 (22), p.1627-1632

Ort / Verlag

Boston: Massachusetts Medical Society

Erscheinungsjahr

2000

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract. Since the cause of the disease is unknown, 1 – 4 nonspecific antiinflammatory agents such as corticosteroids are frequently prescribed. 5 – 7 However, the long-term use of corticosteroids is poorly tolerated. 8 – 10 Therefore, a safe and effective long-term treatment that eliminates the need for corticosteroids is desirable. Although purine antimetabolites (mercaptopurine and azathioprine) 11 – 13 are moderately effective, the disease often relapses despite treatment with these agents. When used as therapy for rheumatoid arthritis, methotrexate frequently reduces or eliminates the need for corticosteroids. 14 – 16 Therefore, it is reasonable to hypothesize that it may . . .