Brain, behavior, and immunity, 2016-01, Vol.51, p.212-222
2016
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- Autor(en) / Beteiligte
- Titel
- Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking
- Ist Teil von
- Brain, behavior, and immunity, 2016-01, Vol.51, p.212-222
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • We report a novel protective action of estrogen on the BBB. • Estrogen enhances inter-endothelial cell tight junction function. • Estrogen’s actions are mediated by GPR30 signaling and phosphorylation of annexin A1. • Estrogen limits lymphocyte extravasation after challenge with inflammatory cytokines. • Estrogen limits inflammation-induced immune cell trafficking through ERβ/annexin A1 pathways.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2015.08.020Titel-ID: cdi_proquest_miscellaneous_1753486100
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Annexin A1, Annexin A1 - administration & dosage, Annexin A1 - physiology, Blood-Brain Barrier - immunology, Blood-Brain Barrier - metabolism, Blood–brain barrier, Cell Movement - drug effects, Cytokines - metabolism, Estradiol - administration & dosage, Estradiol - physiology, Estrogen, Female, Humans, Inflammation - chemically induced, Inflammation - immunology, Inflammation - physiopathology, Lipopolysaccharides, Lymphocytes, Lymphocytes - drug effects, Lymphocytes - physiology, Male, Mice, Inbred C57BL, Psychiatry, Receptors, Estrogen - metabolism, Receptors, G-Protein-Coupled - metabolism, Tight junction