Details

Autor(en) / Beteiligte

• Mørch, Ýrr
• Hansen, Rune
• Berg, Sigrid
• Åslund, Andreas K. O.
• Glomm, Wilhelm R.
• Eggen, Siv
• Schmid, Ruth
• Johnsen, Heidi
• Kubowicz, Stephan
• Snipstad, Sofie
• Sulheim, Einar
• Hak, Sjoerd
• Singh, Gurvinder
• McDonagh, Birgitte H.
• Blom, Hans
• de Lange Davies, Catharina
• Stenstad, Per M.

Titel

Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery

Ist Teil von

• Contrast media and molecular imaging, 2015-09, Vol.10 (5), p.356-366

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology platform incorporating multiple functionalities, including imaging and therapy in a single system consisting of MBs stabilized by polyethylene glycol (PEG)‐coated polymeric nanoparticles (NPs). The NPs, containing lipophilic drugs and/or contrast agents, are composed of the widely used poly(butyl cyanoacrylate) (PBCA) polymer and prepared in a single step. MBs stabilized by these NPs are subsequently prepared by self‐assembly of NPs at the MB air–liquid interface. Here we show that these MBs can act as contrast agents for conventional ultrasound imaging. Successful encapsulation of iron oxide NPs inside the PBCA NPs is demonstrated, potentially enabling the NP–MBs to be used as magnetic resonance imaging (MRI) and/or molecular ultrasound imaging contrast agents. By precise tuning of the applied ultrasound pulse, the MBs burst and the NPs constituting the shell are released. This could result in increased local deposit of NPs into target tissue, providing improved therapy and imaging contrast compared with freely distributed NPs. Copyright © 2015 John Wiley & Sons, Ltd. We have developed a generic multimodal imaging and drug delivery technology platform composed of polymeric nanoparticles surrounding gas microbubbles. The microbubbles are first used as an ultrasound contrast agent to visualize small blood vessels. Increasing the ultrasound power bursts the microbubbles, releasing single nanoparticles containing drugs and/or contrast agents that can cross the blood vessel wall and reach their target thanks to microbubble‐ and ultrasound‐induced increased vascular permeability.