Clinical infectious diseases, 2012-07, Vol.55 (1), p.e1-e4
2012
Details
- Autor(en) / Beteiligte
- Titel
- Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms
- Ist Teil von
- Clinical infectious diseases, 2012-07, Vol.55 (1), p.e1-e4
- Ort / Verlag
- United States: Oxford University Press
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers (80% vs 20%; P = .03), and median HTLV-1 proviral load was greater in CT/TT than CC carriers (P = .01). Thus, IL28B testing and closer follow-up of HTLV-1 asymptomatic CT/TT carriers is warranted.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1058-4838eISSN: 1537-6591DOI: 10.1093/cid/cis343Titel-ID: cdi_proquest_miscellaneous_1753471334
- Format
- –
- Schlagworte
- Adolescent, Adult, Analysis of Variance, Carrier State - immunology, Carrier State - virology, Child, Child, Preschool, Cohort Studies, Cytokines, Female, Gene expression, Human T-lymphotropic virus, Human T-lymphotropic virus 1, Humans, Infectious diseases, Interferons, Interleukins - genetics, Leukocytes, Mononuclear - cytology, Leukocytes, Mononuclear - immunology, Leukocytes, Mononuclear - virology, Male, Middle Aged, Odds Ratio, Paraparesis, Tropical Spastic - genetics, Paraparesis, Tropical Spastic - immunology, Paraparesis, Tropical Spastic - virology, Polymorphism, Polymorphism, Genetic, Spain, Viral infections, Viruses