Enhancing cellular immunogenicity of MVA-vectored vaccines by utilizing the F11L endogenous promoter
2016
Details
- Autor(en) / Beteiligte
- Titel
- Enhancing cellular immunogenicity of MVA-vectored vaccines by utilizing the F11L endogenous promoter
- Ist Teil von
- Vaccine, 2016-01, Vol.34 (1), p.49-55
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- Elsevier ScienceDirect Journals Complete
- Beschreibungen/Notizen
- Highlights • This study presents the effect of stronger promoters on MVA immunogenicity. • F11 promoter (pF11) enhanced in vivo transgene expression and immunogenicity. • pF11 proved stronger than mH5 and p7.5 promoters. • pF11 was tested with a reporter transgene as well as candidate vaccine antigens. • Mechanisms underlying the improved immunogenicity with pF11 were investigated.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2015.11.028Titel-ID: cdi_proquest_miscellaneous_1753461200
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Antigens, Biomedical research, Clinical trials, Drug Carriers, Ebola virus, Ebolavirus, Enzyme-Linked Immunospot Assay, Female, Gene Expression, Genetic Vectors, Genomes, Immunization, Immunogenicity, Influenza Vaccines - genetics, Influenza Vaccines - immunology, Interferon-gamma - metabolism, Kinases, Leukocytes, Mononuclear - immunology, Lymphocytes, Malaria Vaccines - genetics, Malaria Vaccines - immunology, Medical research, Mice, Inbred BALB C, MVA, Mycobacterium, Promoter, Promoter Regions, Genetic, Proteins, Rodents, Studies, Transgene expression, Transgenes, Treatment Outcome, Vaccine development, Vaccines, Vaccines, Synthetic - genetics, Vaccines, Synthetic - immunology, Vaccinia virus, Vaccinia virus - genetics, Vectors (Biology), Viral vector, Viruses