Details

Autor(en) / Beteiligte

• He, Hong-Zhang
• Chan, Daniel Shiu-Hin
• Leung, Chung-Hang
• Ma, Dik-Lung

Titel

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Ist Teil von

• Chemical communications (Cambridge, England), 2012-10, Vol.48 (76), p.9462-9464

Ort / Verlag

England

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.