Details

Autor(en) / Beteiligte

• Fuccio, Lorenzo
• Guido, Alessandra

Titel

Topical rectal beclomethasone dipropionate treatment for the prevention of radiation-induced bleeding

Ist Teil von

• Gut, 2012-09, Vol.61 (9), p.1369-1369

Ort / Verlag

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

Erscheinungsjahr

2012

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• The development of chronic toxicity is, at least in part, related to the severity of the acute toxicity (the so-called 'consequential late effect') 2 ; however, acute and chronic toxicities do not share the same pathogenetic pathway. 3 Inflammation plays a pivotal role only in the acute phase of radiation toxicity, while wall fibrosis and vascular sclerosis are the prominent structural features in the delayed, chronic phase. [...]based on these evidences, we have recently tested, in a randomised, placebo-controlled, double-blind trial, whether topical rectal treatment with beclomethasone dipropionate (BDP) during radiotherapy prevents radiation-induced side effects by reducing the acute inflammatory response. 4 Patients were treated with a 3 mg BDP enema or identical looking placebo for the entire duration of radiotherapy and immediately after the end of radiotherapy the enema formulation was stopped and patients subsequently received two 3 mg BDP suppositories or identical placebo for 4 weeks.