Details

Autor(en) / Beteiligte

• Leuenberger, Philippe
• Schindler, Christian
• Schwartz, Joel
• Ackermann-Liebrich, Ursula
• Tara, Dana
• Perruchoud, André P
• Wüthrich, Brunello
• Zellweger, Jean-Pierre
• Blaser, Kurt
• Bolognini, Gianfranco
• Bongard, Jean-Pierre
• Brändli, Otto
• Domenighetti, Guido
• Elsasser, Serge
• Grizé, Leticia
• Karrer, Werner
• Keller, Roland
• Künzli, Nino
• Medici, Tullio
• Schöni, Martin H
• Solari, Gianmaria
• Tschopp, Jean-Marie
• Villiger, Beat
• Zemp, Elisabeth

Titel

Occupational Exposure to Inhalative Irritants and Methacholine Responsiveness

Ist Teil von

• Scandinavian Journal of Work, Environment ＆ Health, 2000-04, Vol.26 (2), p.146-152

Ort / Verlag

Helsinki: Scandinavian Journal of Work, Environment ＆ Health

Erscheinungsjahr

2000

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objectives Occupational exposures to inhalative irritants have been associated with an increased reporting of respiratory symptoms in previous studies. Methacholine responsiveness represents a continuous measure of airway responsiveness. As such, it may be less subject to recall bias and more sensitive to detecting effects of occupational exposure on airways. Such effects may be stronger among atopic persons. The objective of the study was to examine the relationship between self-reports of occupational exposure to dusts, gases, vapors, aerosols, and fumes and methacholine responsiveness. Methods A sample was studied of never smokers (N=3044) chosen randomly from 8 areas in Switzerland. Atopy was defined as any positive skin test to 8 inhalative allergens. Nonspecific bronchial reactivity was tested using methacholine chloride and quantified by calculating the slope of the dose-response. Results The methacholine slopes were 19% [95% confidence interval (95% CI) 6—32] higher for never smokers with exposure to dusts, fumes, vapors, gases, or aerosols than for the unexposed group. When only atopic never smokers were examined, the increase was larger (37%, 95% CI 7—75), and for persons with≥2 positive skin prick tests the effect was still higher (42%, 95% CI-1.5—104). Exposure to vapors and aerosols was strongly associated with increased methacholine slopes among the atopic subjects. Conclusions Occupational exposure, particularly to dusts and fumes, was associated with increased bronchial reactivity in never smokers in this study. The magnitude of the effect was larger among atopic subjects.