Details

Autor(en) / Beteiligte

• Zhu, Hui-hui
• Zhao, Xi-bao
• Hu, Wei-wei
• Chen, Wei-lin

Titel

Research progress on ubiquitin-specific protease in antiviral immunity

Ist Teil von

• Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2015-09, Vol.44 (5), p.578-583

Ort / Verlag

China

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Ubiquitin-specific protease(USP), which belongs to cysteine protease, is an important member of the deubiquitinating enzyme family(DUB). USP plays an important role in the immune response against viral infections, in which it can regulate the production of type I interferon through various ways to initiate or weaken the antiviral immune response. USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response. In this article we review the recent progress on roles of USP family in antiviral immune response.