Details

Autor(en) / Beteiligte

• Zhang, Yuyan
• Zhao, Jin
• Ning, Li
• Zhang, Jinling
• Tang, Weijun

Titel

Morphological changes of cerebral cortex in primary open-angle glaucoma patients under magnetic resonance imaging

Ist Teil von

• Zhong hua yi xue za zhi, 2015-09, Vol.95 (34), p.2779-2782

Ort / Verlag

China

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• To observe the morphology changes of cerebral cortex in primary open-angle glaucoma (POAG) patients, and to explore the damage mechanism in the central nerve system. 30 patients, 19 males and 11 females (age ranged from 26 to 82 years old), who were diagnosed with POAG in the department of ophthalmology at Huashan Hospital of Fudan University from February 2011 to December 2012 were enrolled. Meanwhile, additional 30 age- and sex- matched patients were collected as controls. All subjects underwent a complete ophthalmic evaluation. As for magnetic resonance imaging (MRI), we adopted the scans of T1WI, T2WI and fluid attenuated inversion recovery (FLAIR) on a Siemens Magneton Verio 3T MRI machine with a 12-channel head coil. Subjects with space occupying or vascular lesion in brain imaging were excluded from the study. The three-dimensional magnetization prepared rapid acquisition gradient echo sequence (3D-MPRAGE) was used to acquire the volume data of whole brain of all subjects. SPM8 and VBM8 toolbox were us