Toxicon (Oxford), 2000-08, Vol.38 (8), p.1009-1014
2000
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- Autor(en) / Beteiligte
- Titel
- Cloning and characterization of a cDNA sequence encoding the precursor of a chlorotoxin-like peptide from the Chinese scorpion Buthus martensii Karsch
- Ist Teil von
- Toxicon (Oxford), 2000-08, Vol.38 (8), p.1009-1014
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2000
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- A full-length cDNA sequence encoding the precursor of a venom peptide with homology to chlorotoxin (named BmKCT) was isolated from a cDNA library made from the venom glands of the Chinese Scorpion Buthus martensii Karsch. The encoded precursor of BmKCT was 59 amino acid residues long including a signal peptide of 24 residues and a mature toxin of 35 residues with four disulfide bridges. The sequence of BmKCT is similar (68% identities) to that of chlorotoxin isolated from Leiurus quinguestriatus quinquestriatus. BmKCT is the first report of the cDNA sequences encoding four-disulfide-bridged short-chain toxins from Buthus martensuii Karsch so far.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0041-0101eISSN: 1879-3150DOI: 10.1016/S0041-0101(99)00212-3Titel-ID: cdi_proquest_miscellaneous_17521996
- Format
- –
- Schlagworte
- Amino Acid Sequence, amino acid sequences, Animal poisons toxicology. Antivenoms, Animals, Base Sequence, Biological and medical sciences, BmKCT, Buthidae, Buthus martensi, Buthus martensii, cDNA sequence, Chlorotoxin, Cloning, Molecular, complementary DNA, DNA - biosynthesis, DNA - chemistry, genbank/af135821, Gene Library, Medical sciences, mesobuthus martensi, Molecular Sequence Data, molecular sequence dta, Neurotoxins - genetics, nucleotide sequences, Oligonucleotides - chemical synthesis, peptides, Peptides - genetics, precursors, Scorpion toxin, Scorpion Venoms - genetics, Scorpiones, Scorpions - genetics, signal peptide, Toxicology, venoms