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Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy
Ist Teil von
Analytical and bioanalytical chemistry, 2015-03, Vol.407 (9), p.2365-2371
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
An analytical method using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was developed and applied to assess enrichment of
10
B-containing
p
-boronophenylalanine-fructose (BPA-f) and its pharmacokinetic distribution in human tissues after application for boron neutron capture therapy (BNCT). High spatial resolution (50 μm) and limits of detection in the low parts-per-billion range were achieved using a Nd:YAG laser of 213 nm wavelength. External calibration by means of
10
B-enriched standards based on whole blood proved to yield precise quantification results. Using this calibration method, quantification of
10
B in cancerous and healthy tissue was carried out. Additionally, the distribution of
11
B was investigated, providing
10
B enrichment in the investigated tissues. Quantitative imaging of
10
B by means of LA-ICP-MS was demonstrated as a new option to characterise the efficacy of boron compounds for BNCT.