Brain, behavior, and immunity, 2015-10, Vol.49, p.322-336
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation
- Ist Teil von
- Brain, behavior, and immunity, 2015-10, Vol.49, p.322-336
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Human stroke patients show reduced levels of interleukin-33 inhibitory receptor sST2. • Interleukin-33 administration is protective in a mouse model of cerebral stroke. • Interleukin-33 administration increased the brain and peripheral levels of interleukin-4. • Modulation of peripheral immunity impacts the outcome of stroke.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2015.06.013Titel-ID: cdi_proquest_miscellaneous_1746877895
- Format
- –
- Schlagworte
- Aged, Allergy and Immunology, Animals, Astrocytes - metabolism, Brain - drug effects, Brain - immunology, Brain - metabolism, Brain Ischemia - blood, Brain Ischemia - immunology, Brain Ischemia - prevention & control, Cells, Cultured, Cerebral stroke, Cytokines, Cytokines - metabolism, Female, Humans, Inflammation, Inflammation - metabolism, Inflammation - prevention & control, Interleukin, Interleukin-33 - administration & dosage, Interleukin-33 - blood, Interleukin-4 - metabolism, Macrophages - drug effects, Macrophages - immunology, Male, Mice, Mice, Inbred BALB C, Microglia - drug effects, Microglia - immunology, Motor Activity - drug effects, Peripheral immune system, Psychiatry, Receptors, Somatostatin - blood, Recombinant Proteins - administration & dosage, Spleen - drug effects, Spleen - immunology, Spleen - metabolism, Stroke - blood, Stroke - immunology, Stroke - prevention & control, T-Lymphocytes - metabolism