Details

Autor(en) / Beteiligte

• Zhu, Zhi
• Guan, Zhichao
• Liu, Dan
• Jia, Shasha
• Li, Jiuxing
• Lei, Zhichao
• Lin, Shuichao
• Ji, Tianhai
• Tian, Zhongqun
• Yang, Chaoyong James

Titel

Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis

Ist Teil von

• Angewandte Chemie (International ed.), 2015-09, Vol.54 (36), p.10448-10453

Auflage

International ed. in English

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Herein, we demonstrate that a very familiar, yet underutilized, physical parameter—gas pressure—can serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas‐generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low‐cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings. Pressure points: A very familiar, yet underutilized, physical parameter—gas pressure—can serve as the signal readout for highly sensitive bioanalysis. Combining the decomposition of H2O2 catalyzed by catalase or Pt nanoparticles with an antibody‐based sandwich assay allows the detection of various analytes. This new signaling strategy opens up simple, portable, yet highly sensitive biomedical analysis in a variety of settings.