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Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis
Ist Teil von
Angewandte Chemie (International ed.), 2015-09, Vol.54 (36), p.10448-10453
Auflage
International ed. in English
Ort / Verlag
Weinheim: WILEY-VCH Verlag
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Herein, we demonstrate that a very familiar, yet underutilized, physical parameter—gas pressure—can serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas‐generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low‐cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings.
Pressure points: A very familiar, yet underutilized, physical parameter—gas pressure—can serve as the signal readout for highly sensitive bioanalysis. Combining the decomposition of H2O2 catalyzed by catalase or Pt nanoparticles with an antibody‐based sandwich assay allows the detection of various analytes. This new signaling strategy opens up simple, portable, yet highly sensitive biomedical analysis in a variety of settings.