Details

Autor(en) / Beteiligte

• Lee, Cheng-Yu
• Chen, Yun-Chung
• Lin, Hao-Chun
• Jhong, Yuandong
• Chang, Chih-Wei
• Tsai, Ching-Hua
• Kao, Chai-Lin
• Chien, Tun-Cheng

Titel

Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore

Ist Teil von

• Tetrahedron, 2012-07, Vol.68 (29), p.5898-5907

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• A facile and effective synthesis for a wide variety of 4-arylidene-5-imidazolinone derivatives was developed. 4-Arylidene-5-oxazolinones were prepared by Erlenmeyer azlactone synthesis from N-acylglycines and arylaldehydes. The ring-opening reactions of the 4-arylidene-5-oxazolinones with primary amines afforded 2-acylamino-3-arylacrylamides in excellent yields. A new dehydrative cyclization of the 2-acylamino-3-arylacrylamides in pyridine under reflux furnished the corresponding 4-arylidene-5-imidazolinones in good yields. [Display omitted]