Details

Autor(en) / Beteiligte

• Bie, Zijun
• Chen, Yang
• Ye, Jin
• Wang, Shuangshou
• Liu, Zhen

Titel

Boronate-Affinity Glycan-Oriented Surface Imprinting: A New Strategy to Mimic Lectins for the Recognition of an Intact Glycoprotein and Its Characteristic Fragments

Ist Teil von

• Angewandte Chemie (International ed.), 2015-08, Vol.54 (35), p.10211-10215

Auflage

International ed. in English

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Lectins possess unique binding properties and are of particular value in molecular recognition. However, lectins suffer from several disadvantages, such as being hard to prepare and showing poor storage stability. Boronate‐affinity glycan‐oriented surface imprinting was developed as a new strategy for the preparation of lectin‐like molecularly imprinted polymers (MIPs). The prepared MIPs could specifically recognize an intact glycoprotein and its characteristic fragments, even within a complex sample matrix. Glycan‐imprinted MIPs could thus prove to be powerful tools for important applications such as proteomics, glycomics, and diagnostics. Sweet‐test thing: Boronate‐affinity glycan‐oriented surface imprinting was used to prepare molecularly imprinted polymers (MIPs) with lectin‐like binding properties. As a proof of principle, glycan‐imprinted magnetic nanoparticles (MNPs) that enable the recognition of an intact glycoprotein and its characteristic fragments through binding to the attached glycans were prepared.