Details

Autor(en) / Beteiligte

• Zhong, Cheng
• Gautam, Lekh Nath S.
• Wang, Dawei
• Akhmedov, Novruz G.
• Petersen, Jeffrey L.
• Shi, Xiaodong

Titel

Amine nucleophilic addition to nitroalkene as a new practical approach for the synthesis of fully substituted isoxazoline- N-oxide

Ist Teil von

• Tetrahedron, 2011-06, Vol.67 (24), p.4402-4411

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The secondary amine nucleophilic addition to the nitroalkene was used to generate the active nitronate intermediate, followed by the sequential addition to aldehyde and ylide, giving the fully substituted isoxazoline- N-oxide in one-pot fashion. Mechanistic studies revealed the equilibrium nature of the diene intermediates, which provide the foundation for the asymmetric synthesis of this interesting heterocycles. [Display omitted]