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Extent of resection and overall survival for patients with atypical and malignant meningioma
Cancer, 2015-12, Vol.121 (24), p.4376-4381
Aizer, Ayal A.
Bi, Wenya Linda
Kandola, Manjinder S.
Lee, Eudocia Q.
Nayak, Lakshmi
Rinne, Mikael L.
Norden, Andrew D.
Beroukhim, Rameen
Reardon, David A.
Wen, Patrick Y.
Al‐Mefty, Ossama
Arvold, Nils D.
Dunn, Ian F.
Alexander, Brian M.
2015
Details
Autor(en) / Beteiligte
Aizer, Ayal A.
Bi, Wenya Linda
Kandola, Manjinder S.
Lee, Eudocia Q.
Nayak, Lakshmi
Rinne, Mikael L.
Norden, Andrew D.
Beroukhim, Rameen
Reardon, David A.
Wen, Patrick Y.
Al‐Mefty, Ossama
Arvold, Nils D.
Dunn, Ian F.
Alexander, Brian M.
Titel
Extent of resection and overall survival for patients with atypical and malignant meningioma
Ist Teil von
Cancer, 2015-12, Vol.121 (24), p.4376-4381
Ort / Verlag
United States
Erscheinungsjahr
2015
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND The prognosis for patients with atypical and malignant meningioma is guarded; whether the extent of resection is associated with survival‐based outcomes in this population remains poorly defined. This study investigated the association between gross total resection (GTR) and all‐cause mortality in patients with atypical and malignant meningioma. METHODS The Surveillance, Epidemiology, and End Results program was used to identify 575 and 64 patients betweens the ages of 18 and 70 years who were diagnosed with atypical and malignant meningioma, respectively, between 2004 and 2009. Multivariate Cox proportional hazards regression was used to assess the adjusted impact of GTR versus subtotal resection on all‐cause mortality. RESULTS Baseline patient characteristics were similar for patients who did undergo GTR and patients who did not undergo GTR. The 5‐year overall survival rates were 91.3% (95% confidence interval [CI], 86.2%‐94.5%) and 78.2% (95% CI, 70.0%‐84.3%) for patients with atypical meningioma who did and did not undergo GTR, respectively, and 64.5% (95% CI, 45.9%‐78.1%) and 41.1% (95% CI, 17.9%‐63.1%) for patients with malignant meningioma who did and did not undergo GTR, respectively. After adjustments for available, pertinent confounding variables, GTR was associated with lower all‐cause mortality in patients with atypical (hazard ratio, 0.39; 95% CI, 0.23‐0.67; P < .001) and malignant meningioma (hazard ratio, 0.35; 95% CI, 0.15‐0.81; P = .01). CONCLUSIONS The extent of resection is a powerful predictor of outcome for patients with atypical and malignant meningioma. These data highlight the hazard associated with the presence of gross tumor bulk after surgery and suggest a value for more extensive resections that should be balanced against the additional potential morbidity. Cancer 2015;121:4376–81. © 2015 American Cancer Society. The extent of resection is associated with survival for patients with atypical and malignant meningioma. Patients may benefit from gross total resection if it can be achieved with acceptable levels of morbidity.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.29639
Titel-ID: cdi_proquest_miscellaneous_1744659437
Format
–
Schlagworte
Adolescent
,
Adult
,
Age Factors
,
Aged
,
anaplastic
,
atypical
,
Cohort Studies
,
Cytoreduction Surgical Procedures
,
death
,
extent of resection
,
Female
,
gross total
,
Humans
,
Male
,
malignant
,
Meningeal Neoplasms - mortality
,
Meningeal Neoplasms - surgery
,
meningioma
,
Meningioma - mortality
,
Meningioma - surgery
,
Middle Aged
,
mortality
,
Neoplasm, Residual
,
Neurosurgical Procedures
,
Prognosis
,
Proportional Hazards Models
,
Retrospective Studies
,
SEER Program
,
surgery
,
survival
,
Survival Rate
,
Tumor Burden
,
Young Adult
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