Details

Autor(en) / Beteiligte

• Shiina, Takashi
• Tamiya, Gen
• Oka, Akira
• Takishima, Nobusada
• Yamagata, Tetsushi
• Kikkawa, Eri
• Iwata, Kyoko
• Tomizawa, Maiko
• Okuaki, Noriko
• Kuwano, Yuko
• Watanabe, Koji
• Fukuzumi, Yasuhito
• Itakura, Shoko
• Sugawara, Chiyo
• Ono, Ayako
• Yamazaki, Masaaki
• Tashiro, Hiroyuki
• Ando, Asako
• Ikemura, Toshimichi
• Soeda, Eiichi
• Kimura, Minoru
• Bahram, Seiamak
• Inoko, Hidetoshi

Titel

Molecular Dynamics of MHC Genesis Unraveled by Sequence Analysis of the 1,796,938-bp HLA Class I Region

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1999-11, Vol.96 (23), p.13282-13287

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

1999

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• The intensely studied MHC has become the paradigm for understanding the architectural evolution of vertebrate multigene families. The 4-Mb human MHC (also known as the HLA complex) encodes genes critically involved in the immune response, graft rejection, and disease susceptibility. Here we report the continuous 1,796,938-bp genomic sequence of the HLA class I region, linking genes between MICB and HLA-F. A total of 127 genes or potentially coding sequences were recognized within the analyzed sequence, establishing a high gene density of one per every 14.1 kb. The identification of 758 microsatellite provides tools for high-resolution mapping of HLA class I-associated disease genes. Most importantly, we establish that the repeated duplication and subsequent diversification of a minimal building block, MIC-HCGIX-3.8-1-P5-HCGIV-HLA class I-HCGII, engendered the present-day MHC. That the currently nonessential HLA-F and MICE genes have acted as progenitors to today's immune-competent HLA-ABC and MICA/B genes provides experimental evidence for evolution by "birth and death", which has general relevance to our understanding of the evolutionary forces driving vertebrate multigene families.