Organic & biomolecular chemistry, 2015-12, Vol.13 (48), p.11593-11596
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors
- Ist Teil von
- Organic & biomolecular chemistry, 2015-12, Vol.13 (48), p.11593-11596
- Ort / Verlag
- England
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A convergent synthesis to access hydrophobic tail analogs and head group modifications of AAL(S) is described. The analogs synthesised were evaluated for their ability to inhibit ceramide synthase 1 and for their cytotoxicity in K562 cells. Our results have identified inhibitors which are non-cytotoxic yet maintain CerS1 inhibition.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1477-0520eISSN: 1477-0539DOI: 10.1039/c5ob01931aTitel-ID: cdi_proquest_miscellaneous_1738821567
- Format
- –
- Schlagworte
- Amino Alcohols - chemical synthesis, Amino Alcohols - chemistry, Amino Alcohols - pharmacology, Cell Survival - drug effects, Enzyme Activation - drug effects, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, Fingolimod Hydrochloride - chemical synthesis, Fingolimod Hydrochloride - chemistry, Fingolimod Hydrochloride - pharmacology, Humans, Hydrophobic and Hydrophilic Interactions, K562 Cells, Models, Biological, Molecular Structure, Oxidoreductases - antagonists & inhibitors