Details

Autor(en) / Beteiligte

• Fujimoto, Takuya
• Andoh, Tooru
• Sudo, Tamotsu
• Fujita, Ikuo
• Fukase, Naomasa
• Takeuchi, Tamotsu
• Sonobe, Hiroshi
• Inoue, Masayoshi
• Hirose, Tkanori
• Sakuma, Toshiko
• Moritake, Hiroshi
• Sugimoto, Tohru
• Kawamoto, Teruya
• Fukumori, Yoshinobu
• Yamamoto, Satomi
• Atagi, Shinji
• Sakurai, Yoshinori
• Kurosaka, Masahiro
• Ono, Koji
• Ichikawa, Hideki
• Suzuki, Minoru

Titel

Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)

Ist Teil von

• Applied radiation and isotopes, 2015-12, Vol.106, p.220-225

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT. •MPNST responds to no effective treatment method other than surgery.•Two clinical cases of MPNST demonstrated the efficacy of BNCT.•MPNST cells and the MPNST-bearing animal model showed high uptake of boron.•The results demonstrated the efficacy of BNCT for MPNST.