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Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts
Ist Teil von
The New England journal of medicine, 2015-11, Vol.373 (21), p.2089-2090
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Implantation of 18 mosaic aneuploid blastocysts obtained through in vitro fertilization into 18 women resulted in six pregnancies of normal karyotype. These pregnancies proceeded to term, with the birth of six healthy babies.
To the Editor:
Chromosomal aneuploidy is recognized as a factor that contributes to unsuccessful embryo implantation and spontaneous abortion. It provides an explanation for the relatively low success rate of in vitro fertilization (IVF) treatments. Preimplantation genetic screening is widely used to identify chromosomally normal (euploid) embryos and select them for intrauterine transfer in order to improve the clinical outcome of IVF.
1
Chromosomal mosaicism is a relatively common finding in IVF-derived human embryos.
2
Mosaic embryos, which are characterized by the presence of a mixture of diploid and aneuploid cell lines, are not usually transferred because they are deemed to be . . .