Details

Autor(en) / Beteiligte

• Zambom de Souza, Alessandra Zanin, M.A
• Zambom, Adriano Zanin, Ph.D
• Abboud, Kahlile Youssef, M.A
• Reis, Sabrina Karen, M.A
• Tannihão, Fabiana, B.A
• Guadagnini, Dioze, M.A
• Saad, Mario J.A., Ph.D
• Prada, Patricia Oliveira, Ph.D

Titel

Oral supplementation with l -glutamine alters gut microbiota of obese and overweight adults: A pilot study

Ist Teil von

• Nutrition (Burbank, Los Angeles County, Calif.), 2015-06, Vol.31 (6), p.884-889

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Objective The aim of this study was to determine whether oral supplementation with l -glutamine (GLN) modifies the gut microbiota composition in overweight and obese adults. Methods Thirty-three overweight and obese adults, ages between 23 and 59 y and body mass index between 25.03 and 47.12 kg/m2 , were randomly assigned to receive either oral supplementation with 30 g of l -alanine (ALA group control) or 30 g of GLN (GLN group) daily for 14 d. We analyzed the gut microbiota composition with new-generation sequencing techniques and bioinformatics analysis. Results After 14 d of supplementation, adults in the GLN group exhibited statistically significant differences in the Firmicutes and Actinobacteria phyla compared with those in the ALA group. The ratio of Firmicutes to Bacteroidetes, a good biomarker for obesity, decreased in the GLN group from 0.85 to 0.57, whereas it increased from 0.91 to 1.12 in the ALA group. At the genus level, Dialister , Dorea , Pseudobutyrivibrio , and Veillonella , belonging to the Firmicutes phylum, had statistically significant reduction. Conclusion Oral supplementation with GLN, for a short time, altered the composition of the gut microbiota in overweight and obese humans reducing the Firmicutes to Bacteroidetes ratio, which resembled weight loss programs already seen in the literature.