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Autor(en) / Beteiligte

Titel

Safety and tolerability of a live oral Salmonella typhimurium vaccine candidate in SIV-infected nonhuman primates

Ist Teil von

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

Highlights • An attenuated nontyphoidal Salmonella live oral vaccine is designed by deleting genes guaBA and clpP. • We test the safety of this vaccine in monkeys infected with simian immunodeficiency virus. • The vaccine was safe and well-tolerated, establishing basis for efficacy and protection studies.

Sprache: Englisch
Identifikatoren: ISSN: 0264-410X
eISSN: 1873-2518
DOI: 10.1016/j.vaccine.2013.09.041
Titel-ID: cdi_proquest_miscellaneous_1732836287

Format: –
Schlagworte: Allergy and Immunology, Animals, Applied microbiology, Bacterial Shedding, Bacteriology, Biological and medical sciences, Coinfection, digestive tract, disease incidence, Disease Models, Animal, elderly, Feces - microbiology, Foodborne Diseases - microbiology, Foodborne Diseases - prevention & control, Fundamental and applied biological sciences. Psychology, gastroenteritis, histopathology, hosts, Human immunodeficiency virus, Immunity, Humoral, Immunocompromised Host, immunocompromised population, infants, Intestinal Mucosa - pathology, Lipopolysaccharide Receptors - blood, Lipopolysaccharides - blood, Live oral vaccine, Macaca mulatta, macrophages, Microbiology, Miscellaneous, mortality, multiple drug resistance, neutrophils, Nonhuman primates, Nontyphoidal Salmonella, permeability, Primates, Salmonella Infections, Animal - complications, Salmonella Infections, Animal - immunology, Salmonella Infections, Animal - prevention & control, Salmonella Typhimurium, Salmonella typhimurium - immunology, Salmonella Vaccines - immunology, serotypes, Simian Acquired Immunodeficiency Syndrome - microbiology, Simian immunodeficiency virus, vaccination, vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects), Vaccines, Attenuated - immunology, Virology

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