Neuroscience, 2015-04, Vol.290, p.90-102
2015
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- Autor(en) / Beteiligte
- Titel
- Ischemic tolerance is associated with VEGF-C and VEGFR-3 signaling in the mouse hippocampus
- Ist Teil von
- Neuroscience, 2015-04, Vol.290, p.90-102
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Ischemic preconditioning (IPC) provides robust neuroprotection in the mouse hippocampus. • IPC treatment induces prominent VEGF-C and VEGFR-3 expression in the hippocampus. • IPC markedly increases VEGF-C expression in tolerance-acquired CA1 neurons after severe ischemia. • IPC treatment preserves a sustained VEGFR-3 expression in the tolerant neurons after severe ischemia. • A VEGFR-3 inhibitor abolishes IPC-induced hippocampal tolerance to severe ischemia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2015.01.025Titel-ID: cdi_proquest_miscellaneous_1732823165
- Format
- –
- Schlagworte
- Animals, Brain Ischemia - metabolism, Brain Ischemia - pathology, CA1 Region, Hippocampal - drug effects, CA1 Region, Hippocampal - metabolism, CA1 Region, Hippocampal - pathology, Carotid Artery Diseases, Cell Count, Central Nervous System Agents - pharmacology, cerebral ischemia, Disease Models, Animal, Dose-Response Relationship, Drug, Fluoresceins, Fluorescent Antibody Technique, ischemic preconditioning, Ischemic Preconditioning - methods, ischemic tolerance, Male, Mice, Inbred C57BL, Naphthyridines - pharmacology, Nerve Tissue Proteins - metabolism, Neurology, Neurons - drug effects, Neurons - metabolism, Neurons - pathology, Nuclear Proteins - metabolism, Vascular Endothelial Growth Factor C - metabolism, Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors, Vascular Endothelial Growth Factor Receptor-3 - metabolism, VEGF-C, VEGFR-3