Details

Autor(en) / Beteiligte

• Cho, Jin-Gyeong
• Cha, Byeong-Ju
• Min Lee, Sang
• Shrestha, Sabina
• Jeong, Rak-Hun
• Sung Lee, Dong
• Kim, Youn-Chul
• Lee, Dong-Geol
• Kang, Hee-Cheol
• Kim, Jiyoung
• Baek, Nam-In

Titel

Diterpenes from the Roots of Oryza sativa L. and Their Inhibition Activity on NO Production in LPS-Stimulated RAW264.7 Macrophages

Ist Teil von

• Chemistry & biodiversity, 2015-09, Vol.12 (9), p.1356-1364

Ort / Verlag

Zürich: WILEY-VCH Verlag

Erscheinungsjahr

2015

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Two new pimarane diterpenoids, momilactone D (3) and momilactone E (5), along with three known diterpenoids, momilactone A (1), sandaracopimaradien‐3‐one (2), and oryzalexin A (4) were isolated from Oryza sativa roots. The chemical structures of the compounds were determined by spectroscopic data analysis. The isolated diterpenoids were evaluated for their ability to inhibit NO production and iNOS mRNA and protein expression in LPS‐stimulated RAW264.7 macrophages. Compound 4 showed strong inhibition activity on NO production, and compounds 1 and 4 decreased the expression of iNOS mRNA and protein levels.