Details

Autor(en) / Beteiligte

• Nakajo, Masatoyo
• Jinguji, Megumi
• Fukukura, Yoshihiko
• Kajiya, Yoriko
• Tani, Atushi
• Nakajo, Masayuki
• Nakabeppu, Yoshiaki
• Arimura, Hiroshi
• Nishio, Yoshihiko
• Nakamura, Fumihiko
• Yoshiura, Takashi

Titel

FDG-PET/CT and FLT-PET/CT for differentiating between lipid-poor benign and malignant adrenal tumours

Ist Teil von

• European radiology, 2015-12, Vol.25 (12), p.3696-3705

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To compare F-18-fluorodeoxyglucose (FDG) and F-18-fluorothymidine (FLT) PET/CT examinations for differentiating between benign and malignant adrenal tumours. Methods Thirty lipid-poor benign and 11 malignant tumours of 40 patients were included. FDG- and FLT-based indices including visual score, maximum standardized uptake value (SUVmax) and FDG adrenal lesion/liver SUVmax (A/L SUVmax) or FLT adrenal lesion/back muscle SUVmax (A/B SUVmax) ratio were compared between benign and malignant tumours using the Mann-Whitney’s U or Wilcoxon signed-rank test, and their diagnostic performances were evaluated by means of the area under the curve (AUC) values derived from the receiver operating characteristic analysis. Results All indices were significantly higher in malignant than benign tumours on both images ( p  < 0.05 each). On FDG-PET/CT, the sensitivity, specificity, and accuracy were 91 %, 63 % and 71 % for visual score, 91 %, 67 % and 73 % for SUVmax, and 100 %, 70 % and 78 % for A/L SUVmax ratio, respectively. On FLT-PET/CT, they were 100 %, 97 % and 98 % for visual score, SUVmax and A/B SUVmax ratio, respectively. All FLT indices were significantly higher than those of FDG in AUC ( p  < 0.05 each). Conclusion FLT-PET/CT may be superior to FDG-PET/CT in differentiating lipid-poor benign from malignant adrenal tumours because of higher specificity and accuracy. Key Points • All FDG indices were significantly higher in malignant than in benign tumours . • All FLT indices were significantly higher in malignant than in benign tumours . • All FLT indices were significantly higher than those of FDG in AUC .