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Oxidant- and metal-free synthesis of 4(3H)-quinazolinones from 2-amino-N-methoxybenzamides and aldehydes via acid-promoted cyclocondensation and elimination
Ist Teil von
RSC advances, 2014-01, Vol.4 (50), p.26434-26438
Erscheinungsjahr
2014
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
A series of biologically important 4(3
H
)-quinazolinones were readily synthesized in good to excellent yields from 2-amino-
N
-methoxybenzamides and aldehydes
via
a cascade reaction consisting of AcOH-promoted cyclocondensation and elimination. The current method sets itself apart from the conventional approach utilizing anthranilamide derivatives and aldehydes as building blocks, by its unique features, other than the high yields and one-pot procedure, including the absence of an oxidant, the elimination of a heavy-metal catalyst, and the formation of a non-toxic ester byproduct.